Application of Modelling and Simulation Approaches to Predict Pharmacokinetics of Therapeutic Monoclonal Antibodies in Pediatric Population

Ethical regulations and limited paediatric participants are key challenges that contribute to a median delay of 6 years in paediatric mAb approval.To overcome these barriers, modelling and simulation methodologies have been adopted to design optimized paediatric clinical studies and reduce patient burden.The classical modelling approach in paediatr

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Exploration on Optimized Control Way of D-Amino Acid for Efficiently Mitigating Membrane Biofouling of Membrane Bioreactor

The thorny issue of membrane biofouling in membrane bioreactors (MBR) calls for new effective control measures.Herein, D-amino acid (DAA) was employed to mediate MBR membrane biofouling by inhibiting biofilm information and disintegrating formed biofilm.Different DAA control ways involving membrane property, DAA-adding timing, and DAA-control mode

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CARBON SIZE AND TEMPERATURE EFFECTS TO JIS S45C CARBURIZED STEEL

Wear on a metal can be naturally found in components that operate in a friction environment, such as in a transmission system.However, it can be a substantial problem when the wear rate is not within the permitted limit.Surface hardening is a popular way to improve surface wear resistance for Storage Bag metals with various parameters that can be c

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